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221 Bus 221 Athens

Panepistimioupoli - Akadimia (Circular) — operated by OASA (Athens Urban Transport Organization). Timetable, all 31 stops and route map.ΠΑΝΕΠΙΣΤΗΜΙΟΥΠΟΛΗ - ΑΚΑΔΗΜΙΑ (ΚΥΚΛΙΚΗ)

  • First bus05:35
  • Last bus04:30⁺¹
  • Frequency~38 min
  • Stops31
  • End to end57 min
Urbaneel app: bus 040 timetable at the Syntagma stop
Timetable for every line The whole week, at your stop
Urbaneel app: departures from the Syntagma stop
Departures at every stop Next bus & trolley times, line by line
Urbaneel app: a trip on metro line M3 with walking directions
Door-to-door routes Metro, bus, tram & trolley, step by step
Urbaneel app: map of the stops around Syntagma
Every stop on one map Bus, trolley, metro & tram
Urbaneel app: Panepistimio station on metro line M2
Metro too Next trains at every station

Bus 221 route map

Bus 221 runs from Zografou to Zografou. Every stop is marked. Drag to pan, ctrl+scroll to zoom.

Bus 221 route and timetable

Timetable — departures from Zografou

Monday - Friday 30 departures · 06:55–22:50 · about every 30 min
06 55
07 2957
08 2654
09 2351
10 2049
11 1747
12 1444
13 1141
14 0838
15 0535
16 0240
17 1950
18 1652
19 25
20 0545
21 45
22 50
Saturday 37 departures · 24 hours · about every 38 min
05 35
06 20
07 0550
08 20
09 0540
10 30
11 1045
12 25
13 0040
14 1555
15 30
16 1045
17 25
18 15
19 0535
20 20
21 1055
22 45
23 35
00+1 002555
01+1 2555
02+1 30
03+1 0030
04+1 0030
Sunday 17 departures · 05:40–22:50 · about every 65 min
05 40
06 45
07 50
09 0055
10 40
11 45
12 55
14 05
15 15
16 25
17 30
18 30
19 35
20 50
22 0050

Stops towards Zografou (32)

  1. ZografouΖΩΓΡΑΦΟΥ#000102
  2. KolokotroniΚΟΛΟΚΟΤΡΩΝΗ#200072
  3. 9i Ilision9η ΙΛΙΣΙΩΝ#200070
  4. Palaio TermaΠΑΛΑΙΟ ΤΕΡΜΑ#200044
  5. 7i Ilision7η ΙΛΙΣΙΩΝ#200045
  6. 6i Ilision6η ΙΛΙΣΙΩΝ#200046
  7. 5i Ilision5η ΙΛΙΣΙΩΝ#200047
  8. 4i Ilision4η ΙΛΙΣΙΩΝ#200048
  9. 3i Ilision3η ΙΛΙΣΙΩΝ#200058
  10. Foitit. EstiaΦΟΙΤΗΤ. ΕΣΤΙΑ#200054
  11. 2i Scholeio2η ΣΧΟΛΕΙΟ#061026
  12. Nosok. SyngrouΝΟΣΟΚ. ΣΥΓΓΡΟΥ#060763
  13. PinakothikiΠΙΝΑΚΟΘΗΚΗ#060764
  14. Nosok. EvangelismosΝΟΣΟΚ. ΕΥΑΓΓΕΛΙΣΜΟΣ#060675
  15. RigillisΡΗΓΙΛΛΗΣ#060676
  16. SyntagmaΣΥΝΤΑΓΜΑ#061048
  17. Nomismatiko MouseioΝΟΜΙΣΜΑΤΙΚΟ ΜΟΥΣΕΙΟ#060015
  18. AkadimiasΑΚΑΔΗΜΙΑΣ#060075
  19. KiposΚΗΠΟΣ#060588
  20. Vyzantino Mouseio - RigillisΒΥΖΑΝΤΙΝΟ ΜΟΥΣΕΙΟ - ΡΗΓΙΛΛΗΣ#060589
  21. Nosokomeio EvangelismosΝΟΣΟΚΟΜΕΙΟ ΕΥΑΓΓΕΛΙΣΜΟΣ#060590
  22. KaravelΚΑΡΑΒΕΛ#060762
  23. EffroniouΕΥΦΡΟΝΙΟΥ#230029
  24. 2i Scholeio2η ΣΧΟΛΕΙΟ#230025
  25. Foitit. EstiaΦΟΙΤΗΤ. ΕΣΤΙΑ#200053
  26. 3i Ilision3η ΙΛΙΣΙΩΝ#200059
  27. 4i Ilision4η ΙΛΙΣΙΩΝ#200040
  28. 5i Ilision5η ΙΛΙΣΙΩΝ#200041
  29. 6i Ilision6η ΙΛΙΣΙΩΝ#200042
  30. 7i Ilision7η ΙΛΙΣΙΩΝ#200043
  31. 8i Ilision8η ΙΛΙΣΙΩΝ#200069
  32. ZografouΖΩΓΡΑΦΟΥ#000102

Bus 221 Athens — questions

What time is the first and last bus 221 in Athens?
The first bus 221 departs at 05:35 and the last one at 04:30⁺¹. Times are the scheduled departures from the start of each direction.
How often does bus 221 run?
Bus 221 runs roughly every 38 minutes. OASA operates 204 departures a week across both directions.
Does bus 221 run on weekends?
Yes. Bus 221 runs on both Saturday and Sunday, usually with a reduced timetable compared with weekdays.
How many stops does bus 221 have?
Bus 221 serves 31 stops in Athens.
How long does the bus 221 route take end to end?
A full end-to-end trip on bus 221 takes about 57 minutes according to the schedule OASA published. Real journey times vary with traffic.
Is the bus 221 timetable up to date?
This page repeats the open-data timetable OASA published for 6 July to 6 October 2026, which has not been renewed since. Today's service may differ.

Routes sharing stops with bus 221

All 277 routes in Athens

Timetable data: OASA open data from data.gov.gr, which OASA licenses under CC BY 4.0 on catalog.growthfund.gr. Names transliterated and timetables reformatted by Urbaneel. Page updated 2026-10-27. Schedules change — check the Urbaneel app before you travel.